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KMID : 1101720230270010001
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Physical Activity and Nutrition
2023 Volume.27 No. 1 p.1 ~ p.8
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Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model
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Kim Ki-Bong
Lee Kang-Pa
Kim Jae-Wook
Park Sun-Young
Kim Ji-Su
Ahn Sang-Hyun
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Abstract
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Purpose : Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.
Methods : A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.
Results : MAG (10-100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.
Conclusion : MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.
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KEYWORD
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gastritis, alcohol-induced gastritis, Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, Gardeniae Fructus
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